Genetic risk for schizophrenia and developmental delay is associated with shape and microstructure of midline white-matter structures.

ABSTRACT: Genomic copy number variants (CNVs) are amongst the most highly penetrant genetic risk factors for neuropsychiatric disorders. The scarcity of carriers of individual CNVs and their phenotypical heterogeneity limits investigations of the associated neural mechanisms and endophenotypes. We applied a novel design based on CNV penetrance for schizophrenia (Sz) and developmental delay (DD) that allows us to identify structural sequelae that are most relevant to neuropsychiatric disorders. Our focus on brain structural abnormalities was based on the hypothesis that convergent mechanisms contributing to neurodevelopmental disorders would likely manifest in the macro- and microstructure of white matter and cortical and subcortical grey matter. Twenty one adult participants carrying neuropsychiatri

SUBMITTER: Drakesmith M 

PROVIDER: S-EPMC6389944 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature