Estrogen receptor-α-miR-1271-SNAI2 feedback loop regulates transforming growth factor-β-induced breast cancer progression.

ABSTRACT:

Background

Breast cancer is the most common cancer among women worldwide, and approximately 70% of breast cancers are hormone receptor-positive and express estrogen receptor-α (ERα) or/and progesterone receptor. ERα has been identified to promote the growth of primary breast cancer, however, it can also antagonize signaling pathways that lead to epithelial-mesenchymal transition (EMT), including transforming growth factor-β (TGF-β) signaling. miRNA alteration or dysfunction is involved in cancer development and progression. Although miR-1271 has identified as a tumor suppressor in various cancers, the role of miR-1271 in breast cancer is still limited.

Methods

The effect of miR-1271 on breast cancer progression was investigated both in vitro and in vivo. The EMT-related prot

SUBMITTER: Liu BW 

PROVIDER: S-EPMC6397493 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature