A fruit fly model for studying paclitaxel-induced peripheral neuropathy and hyperalgesia.
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ABSTRACT:
SUBMITTER: Hamoudi Z
PROVIDER: S-EPMC6402077 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
A fruit fly model for studying paclitaxel-induced peripheral neuropathy and hyperalgesia.
Hamoudi Zina Z Khuong Thang Manh TM Cole Tiffany T Neely G Gregory GG
F1000Research 20180123
<b>Background</b>: Paclitaxel-induced peripheral neuropathy is a common and limiting side effect of an approved and effective chemotherapeutic agent. The cause of this nociception is still unknown. <b>Methods</b>: To uncover the mechanism involved in paclitaxel-induced pain, we developed a <i>Drosophila</i> thermal nociceptive model to show the effects of paclitaxel exposure on third instar larvae. <b>Results</b>: We found that paclitaxel increases heat nociception in a dose-dependent manner, an ...[more]
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