Temporal development of the gut microbiome in early childhood from the TEDDY study.

ABSTRACT: The development of the microbiome from infancy to childhood is dependent on a range of factors, with microbial-immune crosstalk during this time thought to be involved in the pathobiology of later life diseases^1-9 such as persistent islet autoimmunity and type 1 diabetes^10-12. However, to our knowledge, no studies have performed extensive characterization of the microbiome in early life in a large, multi-centre population. Here we analyse longitudinal stool samples from 903 children between 3 and 46 months of age by 16S rRNA gene sequencing (n = 12,005) and metagenomic sequencing (n = 10,867), as part of the The Environmental Determinants of Diabetes in the Young (TEDDY) study. We show that the developing gut microbiome undergoes three distinct phases of microbiome pr

SUBMITTER: Stewart CJ 

PROVIDER: S-EPMC6415775 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature