Blimp-1 Rather Than Hobit Drives the Formation of Tissue-Resident Memory CD8⁺ T Cells in the Lungs.

ABSTRACT: Tissue-resident memory CD8⁺ T (T_RM) cells that develop in the epithelia at portals of pathogen entry are important for improved protection against re-infection. CD8⁺ T_RM cells within the skin and the small intestine are long-lived and maintained independently of circulating memory CD8⁺ T cells. In contrast to CD8⁺ T_RM cells at these sites, CD8⁺ T_RM cells that arise after influenza virus infection within the lungs display high turnover and require constant recruitment from the circulating memory pool for long-term persistence. The distinct characteristics of CD8⁺ T_RM cell maintenance within the lungs may suggest a unique program of transcriptional regulation of influenza-

SUBMITTER: Behr FM 

PROVIDER: S-EPMC6416215 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature