Ontology highlight
ABSTRACT:
SUBMITTER: Lv YP
PROVIDER: S-EPMC6447374 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Science advances 20190403 4
The interaction between gastric epithelium and immune response plays key roles in <i>H. pylori</i>-associated pathology. We demonstrated a procolonization and proinflammation role of MMP-10 in <i>H. pylori</i> infection. MMP-10 is elevated in gastric mucosa and is produced by gastric epithelial cells synergistically induced by <i>H. pylori</i> and IL-22 via the ERK pathway. Human gastric MMP-10 was correlated with <i>H. pylori</i> colonization and the severity of gastritis, and mouse MMP-10 from ...[more]