Screening of noise-induced hearing loss (NIHL)-associated SNPs and the assessment of its genetic susceptibility.

ABSTRACT:

Background

The aim of this study was to screen for noise-induced hearing loss (NIHL)-associated single nucleotide polymorphisms (SNPs) and to construct genetic risk prediction models for NIHL in a Chinese population.

Methods

Four hundred seventy-six subjects with NIHL and 476 matched controls were recruited from a cross-sectional survey on NIHL in China. A total of 83 candidate SNPs were genotyped using nanofluidic dynamic arrays on a Fluidigm platform. NIHL-associated SNPs were screened with a multiple logistic model, and a genetic risk model was constructed based on the genetic risk score (GRS). The results were validated using a prospective cohort population.

Results

Seven SNPs in the CDH23, PCDH15, EYA4, MYO1A, KCNMA1, and OTOG genes were significantly (P < 0.05)

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6449917 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature