Cortical Morphometry in the Psychosis Risk Period: A Comprehensive Perspective of Surface Features.

ABSTRACT:

Background

Gyrification features reflect brain development in the early prenatal environment. Clarifying the nature of these features in psychosis can help shed light on the role of early developmental insult. However, the literature is currently widely discrepant, which may reflect confounds related to formally psychotic patient populations or overreliance on a single feature of cortical surface morphometry (CSM).

Methods

This study compares CSM features of gyrification in clinical high-risk (n = 43) youths during the prodromal risk period to typically developing control subjects over two time points across three metrics: local gyrification index, mean curvature index, and sulcal depth (improving resolution and examination of change over 1 year).

Results

Gyrification

SUBMITTER: Damme KSF 

PROVIDER: S-EPMC6506173 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature