Methodological factors influencing inhalation bioaccessibility of metal(loid)s in PM_2.5 using simulated lung fluid.

ABSTRACT: In this study, methodological factors influencing the dissolution of metal(loid)s in simulated lung fluid (SLF) was assessed in order to develop a standardised method for the assessment of inhalation bioaccessibility in PM_2.5. To achieve this aim, the effects of solid to liquid (S/L) ratio (1:100 to 1:5000), agitation (magnetic agitation, occasional shaking, orbital and end-over-end rotation), composition of SLF (artificial lysosomal fluid: ALF; phagolysosomal simulant fluid: PSF) and extraction time (1-120 h) on metal(loid) bioaccessibility were investigated using PM_2.5 from three Australian mining/smelting impacted soils and a certified reference material. The results highlighted that SLF composition significantly (p < 0.001) influenced metal(loid) bioaccessibility

SUBMITTER: Kastury F 

PROVIDER: S-EPMC6517839 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature