Neuropathology changed by 3- and 6-months low-level PM_2.5 inhalation exposure in spontaneously hypertensive rats.

ABSTRACT:

Background

Epidemiological evidence has linked fine particulate matter (PM_2.5) to neurodegenerative diseases; however, the toxicological evidence remains unclear. The objective of this study was to investigate the effects of PM_2.5 on neuropathophysiology in a hypertensive animal model. We examined behavioral alterations (Morris water maze), lipid peroxidation (malondialdehyde (MDA)), tau and autophagy expressions, neuron death, and caspase-3 levels after 3 and 6 months of whole-body exposure to urban PM_2.5 in spontaneously hypertensive (SH) rats.

Results

SH rats were exposed to S-, K-, Si-, and Fe-dominated PM_2.5 at 8.6 ± 2.5 and 10.8 ± 3.8 μg/m³ for 3 and 6 months, respectively. We observed no significant alterations in

SUBMITTER: Chuang HC 

PROVIDER: S-EPMC7691081 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature