The Association of Multimorbidity With Preclinical AD Stages and SNAP in Cognitively Unimpaired Persons.

ABSTRACT:

Background

Multimorbidity (defined as ≥2 chronic conditions) has been associated with increased risk of mild cognitive impairment and cross-sectionally with imaging biomarkers of neurodegeneration in cognitively unimpaired persons aged ≥70 years. Its association with preclinical Alzheimer's disease stages has not been studied in detail yet. The objective of the study was to assess the cross-sectional association of multimorbidity with preclinical Alzheimer's disease stages and suspected non-amyloid pathophysiology in cognitively unimpaired participants of the Mayo Clinic Study of Aging (≥50 years of age).

Methods

The study included 1,535 cognitively unimpaired participants with multimorbidity, 11C-PiB positron emission topography and magnetic resonance imaging data available

SUBMITTER: Vassilaki M 

PROVIDER: S-EPMC6521911 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature