Inorganic nitrate, hypoxia, and the regulation of cardiac mitochondrial respiration-probing the role of PPARα.

ABSTRACT: Dietary inorganic nitrate prevents aspects of cardiac mitochondrial dysfunction induced by hypoxia, although the mechanism is not completely understood. In both heart and skeletal muscle, nitrate increases fatty acid oxidation capacity, and in the latter case, this involves up-regulation of peroxisome proliferator-activated receptor (PPAR)α expression. Here, we investigated whether dietary nitrate modifies mitochondrial function in the hypoxic heart in a PPARα-dependent manner. Wild-type (WT) mice and mice without PPARα (Ppara^-/-) were given water containing 0.7 mM NaCl (control) or 0.7 mM NaNO₃ for 35 d. After 7 d, mice were exposed to normoxia or hypoxia (10% O₂) for the remainder of the study. Mitochondrial respiratory function and metabolism were

SUBMITTER: Horscroft JA 

PROVIDER: S-EPMC6529343 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature