PEG hydrogel containing calcium-releasing particles and mesenchymal stromal cells promote vessel maturation.

ABSTRACT: The use of human mesenchymal stromal cells (hMSC) for treating diseased tissues with poor vascularization has received significant attention, but low cell survival has hampered its translation to the clinic. Bioglasses and glass-ceramics have also been suggested as therapeutic agents for stimulating angiogenesis in soft tissues, but these effects need further evaluation in vivo. In this study, calcium-releasing particles and hMSC were combined within a hydrogel to examine their vasculogenic potential in vitro and in vivo. The particles provided sustained calcium release and showed proangiogenic stimulation in a chorioallantoic membrane (CAM) assay. The number of hMSC encapsulated in a degradable RGD-functionalized PEG hydrogel containing particles remained constant over time and IGF-1 rele

SUBMITTER: Navarro-Requena C 

PROVIDER: S-EPMC6534820 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature