Maternal genitourinary infections and risk of birth defects in the National Birth Defects Prevention Study.

ABSTRACT:

Background

Genitourinary infections (GUIs) are common among sexually active women. Yet, little is known about the risk of birth defects associated with GUIs.

Methods

Using data from the National Birth Defects Prevention Study, a multisite, population-based, case-control study, we assessed self-reported maternal GUIs in the month before through the third month of pregnancy (periconception) from 29,316 birth defect cases and 11,545 unaffected controls. We calculated odds ratios (ORs) and 95% confidence intervals to estimate the risk of 52 major structural birth defects associated with GUIs. We also calculated risk of birth defects associated with each type of GUI: urinary tract infection (UTI) and sexually transmitted infection (STI).

Results

In our analysis, 10% (n = 2

SUBMITTER: Howley MM 

PROVIDER: S-EPMC6543540 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature