Dataset Information

Adrenal function links to early postnatal growth and blood pressure at age 6 in children born extremely preterm.

ABSTRACT:

Background

Low birth weight in term-born individuals correlates with adverse cardiometabolic outcomes; excess glucocorticoid exposure has been linked to these relationships. We hypothesized that cortisol and adrenal androgens would correlate inversely with birthweight and directly with markers of cardiometabolic risk in school-aged children born extremely preterm; further, preterm-born would have increased cortisol and adrenal androgens compared to term-born children.

Methods

Saliva samples were obtained at age 6 from 219 preterm-born children followed since birth and 40 term-born children and analyzed for dehydroepiandrosterone (DHEA) and cortisol. Cortisol was also measured at home (awakening, 30' later, evening).

Results

For preterm-born children, cortisol and DHEA correlated inversely with weight and length Z-scores at 36 weeks PMA and positively with systolic BP. DHEA was higher in preterm-born than term-born children (boys p < 0.01; girls p = 0.04). Cortisol was similar between preterm-born and term-born at study visit; however, preterm-born children showed a blunted morning cortisol. In term-born children, DHEA correlated with BMI (p = 0.04), subscapular, and abdominal skinfold thicknesses (both p < 0.01).

Conclusion

Cortisol and DHEA correlated inversely with early postnatal growth and directly with systolic BP in extremely preterm-born children, suggesting perinatal programming. Blunted morning cortisol may reflect NICU stress, as seen after other adverse childhood experiences (ACEs).

SUBMITTER: Watterberg KL

PROVIDER: S-EPMC6561840 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Adrenal function links to early postnatal growth and blood pressure at age 6 in children born extremely preterm.

Watterberg Kristi L KL Hintz Susan R SR Do Barbara B Vohr Betty R BR Lowe Jean J Newman Jamie E JE Wallace Dennis D Lacy Conra Backstrom CB Davis Elysia Poggi EP Granger Douglas A DA Shankaran Seetha S Payne Allison A Higgins Rosemary D RD

Pediatric research 20181212 3

<h4>Background</h4>Low birth weight in term-born individuals correlates with adverse cardiometabolic outcomes; excess glucocorticoid exposure has been linked to these relationships. We hypothesized that cortisol and adrenal androgens would correlate inversely with birthweight and directly with markers of cardiometabolic risk in school-aged children born extremely preterm; further, preterm-born would have increased cortisol and adrenal androgens compared to term-born children.<h4>Methods</h4>Sali ...[more]

PMID: 30631138

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Dataset Information

Adrenal function links to early postnatal growth and blood pressure at age 6 in children born extremely preterm.

Background

Methods

Results

Conclusion

Publications

Adrenal function links to early postnatal growth and blood pressure at age 6 in children born extremely preterm.

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