Vitamin D and breast cancer: A systematic review and meta-analysis of observational studies.

ABSTRACT:

Context

Breast cancer (BC) is the most common malignancy among women in the US. Vitamin D status and intakes are thought to be inversely associated with BC occurrence.

Objectives

In our systematic review and meta-analysis, we evaluated evidence linking serum 25(OH)D (both in serum and diet) with breast cancer (BC) occurrence.

Data sources and extraction

Only observational studies from databases such as PubMed and Cochrane (January 1st 2000 through March 15th, 2018) were included using PRISMA guidelines. Publication bias and consistency upon replication were assessed, while harmonizing risk ratios (RR, 95% CI) of BC, per fixed increment of 5 exposures [10 ng/mL of 25(OH)D; 100 IU/d for total/dietary vitamin D intakes; vitamin D deficiency; supplement use). RRs were poo

SUBMITTER: Hossain S 

PROVIDER: S-EPMC6570818 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature