Cadherin-11 contributes to liver fibrosis induced by carbon tetrachloride.

ABSTRACT:

Background and aims

Liver fibrosis is characterized by the excessive deposition of extracellular matrix (ECM) leading to impaired function and cirrhosis. Previous reports support a role for cadherin-11 (CDH11) in regulating the development of dermal and pulmonary fibrosis. In the current report, the extent to which CDH11 modulates the development of liver fibrosis induced by carbon tetrachloride (CCL4) was assessed.

Methods

Wild type (WT) and CDH11 deficient (CDH11-/-) mice were treated with CCl4 or vehicle control for 8 weeks to induce liver fibrosis. Liver fibrosis was assessed by histology, collagen content, and RTPCR of fibrotic mediators.

Results

Livers from WT mice treated with CCl4 had increased levels of CDH11 which localized to injured hepatocytes, hepatic st

SUBMITTER: Pedroza M 

PROVIDER: S-EPMC6608953 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature