Uterine Gα_q/11 signaling, in a progesterone-dependent manner, critically regulates the acquisition of uterine receptivity in the female mouse.

ABSTRACT: A nonreceptive uterus is a major cause of embryo implantation failure. This study examined the importance of the Gα_q/11-coupled class of GPCRs as regulators of uterine receptivity. Mice were created lacking uterine Gα_q and Gα₁₁; as a result, signaling by all uterine Gα_q/11-coupled receptors was disrupted. Reproductive profiling of the knockout females revealed that on d 4 of pregnancy, despite adequate serum progesterone (P4) levels and normal P4 receptor (PR) expression, there was no evidence of PR signaling. This resulted in the down-regulation of heart and neural crest derivatives expressed 2, Kruppel-like factor 15, and cyclin G1 and the subsequent persistent proliferation of the luminal epithelium. Aquaporin (Aqp) 11 was also potently down-r

SUBMITTER: de Oliveira V 

PROVIDER: S-EPMC6662978 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature