Ontology highlight
ABSTRACT:
SUBMITTER: Liu D
PROVIDER: S-EPMC6685086 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Immunity 20190620 1
Type 1 CD8α<sup>+</sup> conventional dendritic cells (cDC1s) are required for CD8<sup>+</sup> T cell priming but, paradoxically, promote splenic Listeria monocytogenes infection. Using mice with impaired cDC2 function, we ruled out a role for cDC2s in this process and instead discovered an interleukin-10 (IL-10)-dependent cellular crosstalk in the marginal zone (MZ) that promoted bacterial infection. Mice lacking the guanine nucleotide exchange factor DOCK8 or CD19 lost IL-10-producing MZ B cell ...[more]