Ontology highlight
ABSTRACT:
SUBMITTER: Wei T
PROVIDER: S-EPMC6692335 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Cell death & disease 20190814 8
Previous study indicated that Sirtuin 3 (SIRT3) is a central regulator of adaptive thermogenesis in brown adipose tissue (BAT). Here we investigate the role of SIRT3 in the modulation of cellular phenotype in BAT under high salt intake (HS). HS downregulated SIRT3 level in BAT, accompanied by decreased oxygen consumption rate, and caused a severe loss of BAT characteristics. Mechanically, SIRT3 interacted with pyruvate dehydrogenase E1α (PDHA1) and deacetylated Lys-83 both in vitro and in vivo u ...[more]