Air pollution, particulate matter composition and methylation-based biologic age.

ABSTRACT:

Background

Epigenetic age, as defined by DNA methylation, may be influenced by air pollution exposure.

Objective

To evaluate the relationship between NO₂, particulate matter (PM), PM components and accelerated epigenetic age.

Methods

In a sample of non-Hispanic white women living in the contiguous U.S. (n = 2747), we estimated residential exposure to PM_2.5, PM₁₀ and NO₂ using a model incorporating land-use regression and kriging. Predictive k-means was used to assign participants to clusters representing different PM_2.5 component profiles. We measured DNA methylation (DNAm) in blood using the Illumina's Infinium HumanMethylation450 BeadChip and calculated DNAm age using the Hannum, Horvath and Levine epigenetic cl

SUBMITTER: White AJ 

PROVIDER: S-EPMC6754788 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature