Self-organization of modular network architecture by activity-dependent neuronal migration and outgrowth.

ABSTRACT: The spatial distribution of neurons and activity-dependent neurite outgrowth shape long-range interaction, recurrent local connectivity and the modularity in neuronal networks. We investigated how this mesoscale architecture develops by interaction of neurite outgrowth, cell migration and activity in cultured networks of rat cortical neurons and show that simple rules can explain variations of network modularity. In contrast to theoretical studies on activity-dependent outgrowth but consistent with predictions for modular networks, spontaneous activity and the rate of synchronized bursts increased with clustering, whereas peak firing rates in bursts increased in highly interconnected homogeneous networks. As Ca2+ influx increased exponentially with increasing network recruitment during bur

SUBMITTER: Okujeni S 

PROVIDER: S-EPMC6783273 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature