A circRNA signature predicts postoperative recurrence in stage II/III colon cancer.

ABSTRACT: Accurate risk stratification for patients with stage II/III colon cancer is pivotal for postoperative treatment decisions. Here, we aimed to identify and validate a circRNA-based signature that could improve postoperative prognostic stratification for these patients. In current retrospective analysis, we included 667 patients with R0 resected stage II/III colon cancer. Using RNA-seq analysis of 20 paired frozen tissues collected postoperation, we profiled differential circRNA expression between patients with and without recurrence, followed by quantitative validation. With clinical information, we generated a four-circRNA-based cirScore to classify patients into high-risk and low-risk groups in the training cohort. The patients with high cirScores in the training cohort had a shorter disea

SUBMITTER: Ju HQ 

PROVIDER: S-EPMC6783650 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature