Association of the TNF-α -308G/A polymorphism with lipid profile changes in response to aerobic training program.

ABSTRACT: Promoter polymorphism of the tumor necrosis factor-α (TNF-α) gene is associated with obesity-related traits, although the role of its potential modifying effect on changes in obesity-related parameters achieved through a training program is still unknown. The aim of the present study was to examine whether the TNF-α-308G/A polymorphism (rs1800629) influences the effects of a training program. Accordingly, we studied the alleles and genotypes distribution in a group of 168 Polish Caucasian women measured for selected body mass and composition, as well as biochemical parameters before and after the realization of a 12-week aerobic training program. Our results showed that TNF-α genotypes can modulate training-induced biochemical parameter changes such as lipid profile. We demonstrated that c

SUBMITTER: Leonska-Duniec A 

PROVIDER: S-EPMC6786320 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature