Dataset Information

The PPM1F gene moderates the association between PTSD and cortical thickness.

ABSTRACT:

Background

Evidence suggests that single nucleotide polymorphisms (SNPs) in genes involved in serotonergic signaling and stress response pathways moderate associations between PTSD and cortical thickness. This study examined a genetic regulator of these pathways, the PPM1F gene, which has also been implicated in mechanisms of stress responding and is differentially expressed in individuals with comorbid PTSD and depression compared to controls.

Methods

Drawing from a sample of 240 white non-Hispanic trauma-exposed veterans, we tested 18 SNPs spanning the PPM1F gene for association with PTSD and cortical thickness.

Results

Analyses revealed six PPM1F SNPs that moderated associations between PTSD symptom severity and cortical thickness of bilateral superior frontal and orbitofrontal regions as well as the right pars triangularis (all corrected p's < 0.05) such that greater PTSD severity was related to reduced cortical thickness as a function of genotype. A whole-cortex vertex-wise analysis using the most associated SNP (rs9610608) revealed this effect to be localized to a cluster in the right superior frontal gyrus (cluster-corrected p < 0.02).

Limitations

Limitations of this study include the small sample size and that the sample was all-white, non-Hispanic predominately male veterans.

Conclusions

These results extend prior work linking PPM1F to PTSD and suggest that variants in this gene may have bearing on the neural integrity of the prefrontal cortex (PFC).

SUBMITTER: Sullivan DR

PROVIDER: S-EPMC6791735 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Publications

The PPM1F gene moderates the association between PTSD and cortical thickness.

Sullivan Danielle R DR Morrison Filomene G FG Wolf Erika J EJ Logue Mark W MW Fortier Catherine B CB Salat David H DH Fonda Jennifer R JR Stone Annjanette A Schichman Steven S Milberg William W McGlinchey Regina R Miller Mark W MW

Journal of affective disorders 20190819

<h4>Background</h4>Evidence suggests that single nucleotide polymorphisms (SNPs) in genes involved in serotonergic signaling and stress response pathways moderate associations between PTSD and cortical thickness. This study examined a genetic regulator of these pathways, the PPM1F gene, which has also been implicated in mechanisms of stress responding and is differentially expressed in individuals with comorbid PTSD and depression compared to controls.<h4>Methods</h4>Drawing from a sample of 240 ...[more]

PMID: 31446381

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Dataset Information

The PPM1F gene moderates the association between PTSD and cortical thickness.

Background

Methods

Results

Limitations

Conclusions

Publications

The PPM1F gene moderates the association between PTSD and cortical thickness.

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