The PPM1F gene moderates the association between PTSD and cortical thickness.

ABSTRACT:

Background

Evidence suggests that single nucleotide polymorphisms (SNPs) in genes involved in serotonergic signaling and stress response pathways moderate associations between PTSD and cortical thickness. This study examined a genetic regulator of these pathways, the PPM1F gene, which has also been implicated in mechanisms of stress responding and is differentially expressed in individuals with comorbid PTSD and depression compared to controls.

Methods

Drawing from a sample of 240 white non-Hispanic trauma-exposed veterans, we tested 18 SNPs spanning the PPM1F gene for association with PTSD and cortical thickness.

Results

Analyses revealed six PPM1F SNPs that moderated associations between PTSD symptom severity and cortical thickness of bilateral superior frontal and

SUBMITTER: Sullivan DR 

PROVIDER: S-EPMC6791735 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature