Glutamine and antioxidants in the critically ill patient: a post hoc analysis of a large-scale randomized trial.

ABSTRACT:

Background

The recent large randomized controlled trial of glutamine and antioxidant supplementation suggested that high-dose glutamine is associated with increased mortality in critically ill patients with multiorgan failure. The objectives of the present analyses were to reevaluate the effect of supplementation after controlling for baseline covariates and to identify potentially important subgroup effects.

Materials and methods

This study was a post hoc analysis of a prospective factorial 2 × 2 randomized trial conducted in 40 intensive care units in North America and Europe. In total, 1223 mechanically ventilated adult patients with multiorgan failure were randomized to receive glutamine, antioxidants, both glutamine and antioxidants, or placebo administered separate fro

SUBMITTER: Heyland DK 

PROVIDER: S-EPMC6800175 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature