Asperpyrone A attenuates RANKL-induced osteoclast formation through inhibiting NFATc1, Ca²⁺ signalling and oxidative stress.

ABSTRACT: Imbalance of osteoblast and osteoclast in adult leads to a variety of bone-related diseases, including osteoporosis. Thus, suppressing the activity of osteoclastic bone resorption becomes the main therapeutic strategy for osteoporosis. Asperpyrone A is a natural compound isolated from Aspergillus niger with various biological activities of antitumour, antimicrobial and antioxidant. The present study was designed to investigate the effects of Asperpyrone A on osteoclastogenesis and to explore its underlining mechanism. We found that Asperpyrone A inhibited RANKL-induced osteoclastogenesis in a dose-dependent manner when the concentration reached 1 µm, and with no cytotoxicity until the concentration reached to 10 µm. In addition, Asperpyrone A down-regulated the mRNA and protein expression

SUBMITTER: Chen X 

PROVIDER: S-EPMC6850946 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature