Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.

ABSTRACT:

Importance

Primary open-angle glaucoma presents with increased prevalence and a higher degree of clinical severity in populations of African ancestry compared with European or Asian ancestry. Despite this, individuals of African ancestry remain understudied in genomic research for blinding disorders.

Objectives

To perform a genome-wide association study (GWAS) of African ancestry populations and evaluate potential mechanisms of pathogenesis for loci associated with primary open-angle glaucoma.

Design, settings, and participants

A 2-stage GWAS with a discovery data set of 2320 individuals with primary open-angle glaucoma and 2121 control individuals without primary open-angle glaucoma. The validation stage included an additional 6937 affected individuals and 14 917 una

SUBMITTER: Genetics of Glaucoma in People of African Descent (GGLAD) Consortium 

PROVIDER: S-EPMC6865235 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature