Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy.

ABSTRACT: Skeletal muscle atrophy is a clinically important outcome of disuse because of injury, immobilization, or bed rest. Disuse atrophy is accompanied by mitochondrial dysfunction, which likely contributes to activation of the muscle atrophy program. However, the linkage of muscle mass and mitochondrial energetics during disuse atrophy and its recovery is incompletely understood. Transcriptomic analysis of muscle biopsies from healthy older adults subject to complete bed rest revealed marked inhibition of mitochondrial energy metabolic pathways. To determine the temporal sequence of muscle atrophy and changes in intramyocellular lipid and mitochondrial energetics, we conducted a time course of hind limb unloading-induced atrophy in adult mice. Mitochondrial respiration and calcium retention cap

SUBMITTER: Trevino MB 

PROVIDER: S-EPMC6879870 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature