DECA, A Comprehensive, Automatic Post-processing Program for HDX-MS Data.

ABSTRACT: Amide hydrogen-deuterium exchange mass spectrometry (HDX-MS) has become widely popular for mapping protein-ligand interfaces, for understanding protein-protein interactions, and for discovering dynamic allostery. Several platforms are now available which provide large data sets of amide hydrogen/deuterium exchange mass spectrometry (HDX-MS) data. Although many of these platforms provide some down-stream processing, a comprehensive software that provides the most commonly used down-stream processing tools such as automatic back-exchange correction options, analysis of overlapping peptides, calculations of relative deuterium uptake into regions of the protein after such corrections, rigorous statistical analysis of the significance of uptake differences, and generation of high quality figure

SUBMITTER: Lumpkin RJ 

PROVIDER: S-EPMC6885705 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature