The effects of bioavailable gluconate chelated stannous fluoride dentifrice on gingival bleeding: Meta-analysis of eighteen randomized controlled trials.

ABSTRACT:

Aim

To estimate gingivitis effects of a bioavailable gluconate chelated 0.454% stannous fluoride (SnF₂ ) family of dentifrices in adult subjects versus positive (triclosan) and negative (NaF or MFP) controls when used ≤3 months.

Materials and methods

A meta-analysis evaluated bioavailable gluconate chelated SnF₂ dentifrices versus a negative or positive control for gingival bleeding.

Results

In 18 randomized controlled trials (RCTs) with 2,890 subjects assessing SnF₂ paste versus a negative or positive control, the average number of bleeding sites was reduced by 51% and 31%, respectively. The average change (95% CI) in number of bleeding sites was -16.3 (-27.8, -4.9) versus the negative control and -3.6 (-5.4, -1.8) versus the positive

SUBMITTER: Biesbrock A 

PROVIDER: S-EPMC6899529 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature