Ontology highlight
ABSTRACT:
SUBMITTER: Marie KL
PROVIDER: S-EPMC6965108 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Nature communications 20200116 1
Cutaneous malignant melanoma is an aggressive cancer of melanocytes with a strong propensity to metastasize. We posit that melanoma cells acquire metastatic capability by adopting an embryonic-like phenotype, and that a lineage approach would uncover metastatic melanoma biology. Using a genetically engineered mouse model to generate a rich melanoblast transcriptome dataset, we identify melanoblast-specific genes whose expression contribute to metastatic competence and derive a 43-gene signature ...[more]