The Future of Genomic Studies Must Be Globally Representative: Perspectives from PAGE.
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ABSTRACT:
SUBMITTER: Bien SA
PROVIDER: S-EPMC7012212 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
The Future of Genomic Studies Must Be Globally Representative: Perspectives from PAGE.
Bien Stephanie A SA Wojcik Genevieve L GL Hodonsky Chani J CJ Gignoux Christopher R CR Cheng Iona I Matise Tara C TC Peters Ulrike U Kenny Eimear E EE North Kari E KE
Annual review of genomics and human genetics 20190412
The past decade has seen a technological revolution in human genetics that has empowered population-level investigations into genetic associations with phenotypes. Although these discoveries rely on genetic variation across individuals, association studies have overwhelmingly been performed in populations of European descent. In this review, we describe limitations faced by single-population studies and provide an overview of strategies to improve global representation in existing data sets and ...[more]
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