Human CD4⁺CD103⁺ cutaneous resident memory T cells are found in the circulation of healthy individuals.

ABSTRACT: Tissue-resident memory T cells (T_RM) persist locally in nonlymphoid tissues where they provide frontline defense against recurring insults. T_RM at barrier surfaces express the markers CD103 and/or CD69, which function to retain them in epithelial tissues. In humans, neither the long-term migratory behavior of T_RM nor their ability to reenter the circulation and potentially migrate to distant tissue sites has been investigated. Using tissue explant cultures, we found that CD4⁺CD69⁺CD103⁺ T_RM in human skin can down-regulate CD69 and exit the tissue. In addition, we identified a skin-tropic CD4⁺CD69^-CD103⁺ population in human lymph and blood that is transcriptionally, functionally, an

SUBMITTER: Klicznik MM 

PROVIDER: S-EPMC7057121 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature