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Comparison of Multivendor Single-Voxel MR Spectroscopy Data Acquired in Healthy Brain at 26 Sites.

ABSTRACT: Background The hardware and software differences between MR vendors and individual sites influence the quantification of MR spectroscopy data. An analysis of a large data set may help to better understand sources of the total variance in quantified metabolite levels. Purpose To compare multisite quantitative brain MR spectroscopy data acquired in healthy participants at 26 sites by using the vendor-supplied single-voxel point-resolved spectroscopy (PRESS) sequence. Materials and Methods An MR spectroscopy protocol to acquire short-echo-time PRESS data from the midparietal region of the brain was disseminated to 26 research sites operating 3.0-T MR scanners from three different vendors. In this prospective study, healthy participants were scanned between July 2016 and December 2017. Data were analyzed by using software with simulated basis sets customized for each vendor implementation. The proportion of total variance attributed to vendor-, site-, and participant-related effects was estimated by using a linear mixed-effects model. P values were derived through parametric bootstrapping of the linear mixed-effects models (denoted P_boot). Results In total, 296 participants (mean age, 26 years ± 4.6; 155 women and 141 men) were scanned. Good-quality data were recorded from all sites, as evidenced by a consistent linewidth of N-acetylaspartate (range, 4.4-5.0 Hz), signal-to-noise ratio (range, 174-289), and low Cramér-Rao lower bounds (≤5%) for all of the major metabolites. Among the major metabolites, no vendor effects were found for levels of myo-inositol (P_boot > .90), N-acetylaspartate and N-acetylaspartylglutamate (P_boot = .13), or glutamate and glutamine (P_boot = .11). Among the smaller resonances, no vendor effects were found for ascorbate (P_boot = .08), aspartate (P_boot > .90), glutathione (P_boot > .90), or lactate (P_boot = .28). Conclusion Multisite multivendor single-voxel MR spectroscopy studies performed at 3.0 T can yield results that are coherent across vendors, provided that vendor differences in pulse sequence implementation are accounted for in data analysis. However, the site-related effects on variability were more profound and suggest the need for further standardization of spectroscopic protocols. © RSNA, 2020 Online supplemental material is available for this article.

SUBMITTER: Povazan M

PROVIDER: S-EPMC7104702 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Comparison of Multivendor Single-Voxel MR Spectroscopy Data Acquired in Healthy Brain at 26 Sites.

Považan Michal M Mikkelsen Mark M Berrington Adam A Bhattacharyya Pallab K PK Brix Maiken K MK Buur Pieter F PF Cecil Kim M KM Chan Kimberly L KL Chen David Y T DYT Craven Alexander R AR Cuypers Koen K Dacko Michael M Duncan Niall W NW Dydak Ulrike U Edmondson David A DA Ende Gabriele G Ersland Lars L Forbes Megan A MA Gao Fei F Greenhouse Ian I Harris Ashley D AD He Naying N Heba Stefanie S Hoggard Nigel N Hsu Tun-Wei TW Jansen Jacobus F A JFA Kangarlu Alayar A Lange Thomas T Lebel R Marc RM Li Yan Y Lin Chien-Yuan E CE Liou Jy-Kang JK Lirng Jiing-Feng JF Liu Feng F Long Joanna R JR Ma Ruoyun R Maes Celine C Moreno-Ortega Marta M Murray Scott O SO Noah Sean S Noeske Ralph R Noseworthy Michael D MD Oeltzschner Georg G Porges Eric C EC Prisciandaro James J JJ Puts Nicolaas A J NAJ Roberts Timothy P L TPL Sack Markus M Sailasuta Napapon N Saleh Muhammad G MG Schallmo Michael-Paul MP Simard Nicholas N Stoffers Diederick D Swinnen Stephan P SP Tegenthoff Martin M Truong Peter P Wang Guangbin G Wilkinson Iain D ID Wittsack Hans-Jörg HJ Woods Adam J AJ Xu Hongmin H Yan Fuhua F Zhang Chencheng C Zipunnikov Vadim V Zöllner Helge J HJ Edden Richard A E RAE Barker Peter B PB

Radiology 20200211 1

Background The hardware and software differences between MR vendors and individual sites influence the quantification of MR spectroscopy data. An analysis of a large data set may help to better understand sources of the total variance in quantified metabolite levels. Purpose To compare multisite quantitative brain MR spectroscopy data acquired in healthy participants at 26 sites by using the vendor-supplied single-voxel point-resolved spectroscopy (PRESS) sequence. Materials and Methods An MR sp ...[more]

PMID: 32043950

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Comparison of Multivendor Single-Voxel MR Spectroscopy Data Acquired in Healthy Brain at 26 Sites.

Publications

Comparison of Multivendor Single-Voxel MR Spectroscopy Data Acquired in Healthy Brain at 26 Sites.

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