Mendelian Randomization of Circulating Polyunsaturated Fatty Acids and Colorectal Cancer Risk.

ABSTRACT:

Background

Results from epidemiologic studies examining polyunsaturated fatty acids (PUFA) and colorectal cancer risk are inconsistent. Mendelian randomization may strengthen causal inference from observational studies. Given their shared metabolic pathway, examining the combined effects of aspirin/NSAID use with PUFAs could help elucidate an association between PUFAs and colorectal cancer risk.

Methods

Information was leveraged from genome-wide association studies (GWAS) regarding PUFA-associated SNPs to create weighted genetic scores (wGS) representing genetically predicted circulating blood PUFAs for 11,016 non-Hispanic white colorectal cancer cases and 13,732 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO). Associations per SD increase i

SUBMITTER: Khankari NK 

PROVIDER: S-EPMC7125012 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature