Polyunsaturated fatty acids and diabetic microvascular complications: a Mendelian randomization study.

ABSTRACT:

Background

Observational studies and clinical trials have implicated polyunsaturated fatty acids (PUFAs) in potentially safeguarding against diabetic microvascular complication. Nonetheless, the causal nature of these relationships remains ambiguous due to conflicting findings across studies. This research employs Mendelian randomization (MR) to assess the causal impact of PUFAs on diabetic microvascular complications.

Methods

We identified instrumental variables for PUFAs, specifically omega-3 and omega-6 fatty acids, using the UK Biobank data. Outcome data regarding diabetic microvascular complications were sourced from the FinnGen Study. Our analysis covered microvascular outcomes in both type 1 and type 2 diabetes, namely diabetic neuropathy (DN), diabetic retinopathy (D

SUBMITTER: Liu B 

PROVIDER: S-EPMC11335686 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature