Polyunsaturated fatty acids and risk of Alzheimer's disease: a Mendelian randomization study.

ABSTRACT:

Purpose

Observational studies have suggested that polyunsaturated fatty acids (PUFAs) may decrease Alzheimer's disease (AD) risk. In the present study, we examined this hypothesis using a Mendelian randomization analysis.

Methods

We used summary statistics data for single-nucleotide polymorphisms associated with plasma levels of n-6 PUFAs (linoleic acid, arachidonic acid) and n-3 PUFAs (alpha-linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid), and the corresponding data for AD from a genome-wide association meta-analysis of 63,926 individuals (21,982 diagnosed AD cases, 41,944 controls).

Results

None of the genetically predicted PUFAs was significantly associated with AD risk; odds ratios (95% confidence interval) per 1 SD increase in

SUBMITTER: Tomata Y 

PROVIDER: S-EPMC7230050 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature