Distinct Laminar Requirements for NMDA Receptors in Experience-Dependent Visual Cortical Plasticity.

ABSTRACT: Primary visual cortex (V1) is the locus of numerous forms of experience-dependent plasticity. Restricting visual stimulation to one eye at a time has revealed that many such forms of plasticity are eye-specific, indicating that synaptic modification occurs prior to binocular integration of thalamocortical inputs. A common feature of these forms of plasticity is the requirement for NMDA receptor (NMDAR) activation in V1. We therefore hypothesized that NMDARs in cortical layer 4 (L4), which receives the densest thalamocortical input, would be necessary for all forms of NMDAR-dependent and input-specific V1 plasticity. We tested this hypothesis in awake mice using a genetic approach to selectively delete NMDARs from L4 principal cells. We found, unexpectedly, that both stimulus-selective resp

SUBMITTER: Fong MF 

PROVIDER: S-EPMC7174998 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature