Ontology highlight
ABSTRACT:
SUBMITTER: Wilbrecht L
PROVIDER: S-EPMC2910869 | biostudies-other | 2010 Apr
REPOSITORIES: biostudies-other
Wilbrecht Linda L Holtmaat Anthony A Wright Nick N Fox Kevin K Svoboda Karel K
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100401 14
The stabilization of new spines in the barrel cortex is enhanced after whisker trimming, but its relationship to experience-dependent plasticity is unclear. Here we show that in wild-type mice, whisker potentiation and spine stabilization are most pronounced for layer 5 neurons at the border between spared and deprived barrel columns. In homozygote alphaCaMKII-T286A mice, which lack experience-dependent potentiation of responses to spared whiskers, there is no increase in new spine stabilization ...[more]