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Structural plasticity underlies experience-dependent functional plasticity of cortical circuits.


ABSTRACT: The stabilization of new spines in the barrel cortex is enhanced after whisker trimming, but its relationship to experience-dependent plasticity is unclear. Here we show that in wild-type mice, whisker potentiation and spine stabilization are most pronounced for layer 5 neurons at the border between spared and deprived barrel columns. In homozygote alphaCaMKII-T286A mice, which lack experience-dependent potentiation of responses to spared whiskers, there is no increase in new spine stabilization at the border between barrel columns after whisker trimming. Our data provide a causal link between new spine synapses and plasticity of adult cortical circuits and suggest that alphaCaMKII autophosphorylation plays a role in the stabilization but not formation of new spines.

SUBMITTER: Wilbrecht L 

PROVIDER: S-EPMC2910869 | biostudies-other | 2010 Apr

REPOSITORIES: biostudies-other

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Structural plasticity underlies experience-dependent functional plasticity of cortical circuits.

Wilbrecht Linda L   Holtmaat Anthony A   Wright Nick N   Fox Kevin K   Svoboda Karel K  

The Journal of neuroscience : the official journal of the Society for Neuroscience 20100401 14


The stabilization of new spines in the barrel cortex is enhanced after whisker trimming, but its relationship to experience-dependent plasticity is unclear. Here we show that in wild-type mice, whisker potentiation and spine stabilization are most pronounced for layer 5 neurons at the border between spared and deprived barrel columns. In homozygote alphaCaMKII-T286A mice, which lack experience-dependent potentiation of responses to spared whiskers, there is no increase in new spine stabilization  ...[more]

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