Ontology highlight
ABSTRACT:
SUBMITTER: Chang Z
PROVIDER: S-EPMC7179414 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20200309 5
We developed an efficient method for synthesis of substituted <i>N</i>-benzoylindole via Pd(II)-catalyzed C-H functionalization of substituted <i>N</i>-(2-allylphenyl)benzamide. The reaction showed a broad substrate scope (including <i>N</i>-acetyl and <i>N</i>-Ts substrates) and substituted indoles were obtained in good to excellent yields. The most distinctive feature of this method lies in the high selectivity for <i>N</i>-benzoylindole over benzoxazine, and this is the first example of Pd(II ...[more]