Dataset Information

Mortality Risk in Irritable Bowel Syndrome: Results From a Nationwide Prospective Cohort Study.

ABSTRACT:

Introduction

Mortality concern is a frequent driver of care seeking in patients with irritable bowel syndrome (IBS). Data on mortality in IBS are scarce, and population-based studies have been limited in size. We examined mortality in IBS.

Methods

A nationwide, matched, population-based cohort study was conducted in Sweden. We identified 45,524 patients undergoing a colorectal biopsy at any of Sweden's 28 pathology departments and with a diagnosis of IBS from 2002 to 2016 according to the National Patient Register, a nationwide registry of inpatient and outpatient specialty care. We compared the mortality risk between these individuals with IBS and age- and sex-matched reference individuals (n = 217,316) from the general population and siblings (n = 53,228). In separate analyses, we examined the role of mucosal appearance for mortality in IBS. Finally, we examined mortality in 41,427 patients with IBS not undergoing a colorectal biopsy. Cox regression estimated hazard ratios (HRs) for death.

Results

During follow-up, there were 3,290 deaths in individuals with IBS (9.4/1,000 person-years) compared with 13,255 deaths in reference individuals (7.9/1,000 person-years), resulting in an HR of 1.10 (95% confidence interval [CI] = 1.05-1.14). After adjustment for confounders, IBS was not linked to mortality (HR = 0.96; 95% CI = 0.92-1.00). The risk estimates were neutral when patients with IBS were compared with their siblings. The underlying mucosal appearance on biopsy had only a marginal impact on mortality, and patients with IBS not undergoing a colorectal biopsy were at no increased risk of death (HR = 1.02; 95% CI = 0.99-1.06).

Discussion

IBS does not seem to confer an increased risk of death.

SUBMITTER: Staller K

PROVIDER: S-EPMC7196022 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Publications

Mortality Risk in Irritable Bowel Syndrome: Results From a Nationwide Prospective Cohort Study.

Staller Kyle K Olén Ola O Söderling Jonas J Roelstraete Bjorn B Törnblom Hans H Khalili Hamed H Joshi Amit D AD Nguyen Long H LH Song Mingyang M Kuo Braden B Chan Andrew T AT Ludvigsson Jonas F JF

The American journal of gastroenterology 20200501 5

<h4>Introduction</h4>Mortality concern is a frequent driver of care seeking in patients with irritable bowel syndrome (IBS). Data on mortality in IBS are scarce, and population-based studies have been limited in size. We examined mortality in IBS.<h4>Methods</h4>A nationwide, matched, population-based cohort study was conducted in Sweden. We identified 45,524 patients undergoing a colorectal biopsy at any of Sweden's 28 pathology departments and with a diagnosis of IBS from 2002 to 2016 accordin ...[more]

PMID: 32108661

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Dataset Information

Mortality Risk in Irritable Bowel Syndrome: Results From a Nationwide Prospective Cohort Study.

Introduction

Methods

Results

Discussion

Publications

Mortality Risk in Irritable Bowel Syndrome: Results From a Nationwide Prospective Cohort Study.

Similar Datasets

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