Involvement of fat mass and obesity gene (FTO) in the anti-obesity action of Annona muricata Annonaceae: in silico and in vivo studies.

ABSTRACT:

Background

Annona muricata (Annonaceae) known as soursop is a common tropical plant species known for its numerous medicinal properties including obesity. The underlying mechanism of anti-obesity effect of A. muricata was investigated. The fat mass and obesity associated protein (FTO) is a validated potential target for anti-obesity drugs.

Methods

The interaction of compounds previously characterized from A. muricata was investigated against FTO using Autodock Vina. Also, modulation of FTO and STAT-3 mRNA expression by A. muricata was investigated in high fat diet induced obese rats (HFDR) using RT-PCR.

Results

A significant up-regulation of FTO gene was observed in HFDR when compared to control rats, while administration of A. muricata<

SUBMITTER: Elekofehinti OO 

PROVIDER: S-EPMC7223953 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature