From Polygenic Scores to Precision Medicine in Alzheimer's Disease: A Systematic Review.

ABSTRACT:

Background

Late-onset Alzheimer's disease (AD) is highly heritable. The effect of many common genetic variants, single nucleotide polymorphisms (SNPs), confer risk. Variants are clustered in areas of biology, notably immunity and inflammation, cholesterol metabolism, endocytosis, and ubiquitination. Polygenic scores (PRS), which weight the sum of an individual's risk alleles, have been used to draw inferences about the pathological processes underpinning AD.

Objective

This paper aims to systematically review how AD PRS are being used to study a range of outcomes and phenotypes related to neurodegeneration.

Methods

We searched the literature from July 2008-July 2018 following PRISMA guidelines.

Results

57 studies met criteria. The AD PRS can distinguish AD cases

SUBMITTER: Harrison JR 

PROVIDER: S-EPMC7242840 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature