Role of Polygenic Risk Score in Cancer Precision Medicine of Non-European Populations: A Systematic Review.

ABSTRACT: The development of new screening methods and diagnostic tests for traits, common diseases, and cancer is linked to the advent of precision genomic medicine, in which health care is individually adjusted based on a person's lifestyle, environmental influences, and genetic variants. Based on genome-wide association study (GWAS) analysis, rapid and continuing progress in the discovery of relevant single nucleotide polymorphisms (SNPs) for traits or complex diseases has increased interest in the potential application of genetic risk models for routine health practice. The polygenic risk score (PRS) estimates an individual's genetic risk of a trait or disease, calculated by employing a weighted sum of allele counts combined with non-genetic variables. However, 98.38% of PRS records held in publ

SUBMITTER: Junior HLR 

PROVIDER: S-EPMC9406904 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature