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Gestational diabetes mellitus, prenatal air pollution exposure, and autism spectrum disorder.

ABSTRACT: BACKGROUND:Ambient air pollution and maternal diabetes may affect common biological pathways underlying adverse neurodevelopmental effects. However, joint effects of maternal diabetes and air pollution on autism spectrum disorder (ASD) have not been studied. OBJECTIVE:We evaluated whether prenatal and early-life air pollution exposure interacts with maternal diabetes status to affect ASD risk. METHODS:This retrospective cohort study included 246,420 singleton children born in Kaiser Permanente Southern California hospitals in 1999-2009. Children were followed from birth until age 5, during which 2471 ASD cases were diagnosed. Ozone (O3), particulate matter?

SUBMITTER: Jo H 

PROVIDER: S-EPMC7250244 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Gestational diabetes mellitus, prenatal air pollution exposure, and autism spectrum disorder.

Jo Heejoo H   Eckel Sandrah P SP   Chen Jiu-Chiuan JC   Cockburn Myles M   Martinez Mayra P MP   Chow Ting T   Lurmann Frederick W FW   Funk William E WE   Xiang Anny H AH   McConnell Rob R  

Environment international 20191011 Pt A

<h4>Background</h4>Ambient air pollution and maternal diabetes may affect common biological pathways underlying adverse neurodevelopmental effects. However, joint effects of maternal diabetes and air pollution on autism spectrum disorder (ASD) have not been studied.<h4>Objective</h4>We evaluated whether prenatal and early-life air pollution exposure interacts with maternal diabetes status to affect ASD risk.<h4>Methods</h4>This retrospective cohort study included 246,420 singleton children born  ...[more]

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