Associations between vitamin D receptor gene polymorphisms and chronic spontaneous urticaria in Chinese Han population.

ABSTRACT:

Introduction

Previous studies found that vitamin D receptor (VDR) TaqI, BsmI, FokI and ApaI gene polymorphisms are associated with several inflammatory diseases. However, the relationship between VDR gene polymorphisms and chronic spontaneous urticaria (CSU) is not clear.

Aim

The purpose of our study was to explore the relationship between the polymorphism of VDR and the incidence of chronic spontaneous urticaria in the Chinese Han population. Meanwhile, the vitamin D levels in patients with chronic spontaneous urticaria were also detected and the effects of VDR gene polymorphism on vitamin D levels were detected.

Material and methods

The genotypes of four VDR polymorphisms (TaqI, BsmI, ApaI, and FokI) were studied using allele-specific PCR analysis in 90 CSU patients

SUBMITTER: Ma Y 

PROVIDER: S-EPMC7262806 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature