Thiazide Diuretic-Induced Change in Fasting Plasma Glucose: a Meta-analysis of Randomized Clinical Trials.

ABSTRACT:

Background

Prior meta-analyses measuring thiazide-induced glycemic change have demonstrated an increased risk of incident diabetes; however, this measure's definition has changed over time.

Aim

To determine the magnitude of change in fasting plasma glucose (FPG) for thiazide diuretics.

Data sources

A research librarian designed and conducted searches in Medline®, EMBASE, and EBM Reviews-Cochrane Central Register of Controlled Trials (inception through July 2018) and International Pharmaceutical Abstracts (inception to December 2014).

Study selection

Randomized, controlled trials comparing a thiazide or thiazide-like diuretic to any comparator reporting FPG were identified. Trials enrolling < 50 participants, those with a follow-up period of < 4 weeks, and confe

SUBMITTER: Hall JJ 

PROVIDER: S-EPMC7280437 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature