Hypochloremia Is a Noninvasive Predictor of Mortality in Pulmonary Arterial Hypertension.

ABSTRACT: Background Pulmonary arterial hypertension (PAH) is a lethal disease. In resource-limited countries PAH outcomes are worse because therapy costs are prohibitive. To improve global outcomes, noninvasive and widely available biomarkers that identify high-risk patients should be defined. Serum chloride is widely available and predicts mortality in left heart failure, but its prognostic utility in PAH requires further investigation. Methods and Results In this study 475 consecutive PAH patients evaluated at the University of Minnesota and Vanderbilt University PAH clinics were examined. Clinical characteristics were compared by tertiles of serum chloride. Both the Kaplan-Meier method and Cox regression analysis were used to assess survival and predictors of mortality, respectively. Categorical

SUBMITTER: Prins KW 

PROVIDER: S-EPMC7335577 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature