Slit2 May Underlie Divergent Induction by Thyrotropin of IL-23 and IL-12 in Human Fibrocytes.

ABSTRACT: IL-23 and IL-12, two structurally related heterodimeric cytokines sharing a common subunit, divergently promote Th cell development and expansion. Both cytokines have been implicated in the pathogenesis of thyroid-associated ophthalmopathy (TAO), an autoimmune component of Graves disease. In TAO, CD34⁺ fibrocytes, putatively derived from bone marrow, can be identified in the orbit. There they masquerade as CD34⁺ orbital fibroblasts (OF) (CD34⁺ OF) and cohabitate with CD34^- OF in a mixed fibroblast population (GD-OF). Slit2, a neural axon repellent, is expressed and released by CD34^- OF and dampens the inflammatory phenotype of fibrocytes and CD34⁺ OF. In this study we report that thyrotropin (TSH) and the pathogenic, GD-spec

SUBMITTER: Fernando R 

PROVIDER: S-EPMC7365299 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature